Dante (voice) / Dante / Boy (voice)
Lady (voice) / Mary (voice)
Vergil (voice) / Vergil / Horned Demon (voice)
Arkham / Agni / Rudra (voice) / Rudra / Demon Soldier (voice)
White Rabbit (voice) / White Rabbit / Horned Demon (voice)
Eva (voice) / Echidna / Demon Girl / Eva (voice)
Enzo (voice) / Enzo / Trucker (voice)
Arius (voice)
Baines (voice) / Baines / Soldier #3 (voice)
Baines (voice) / Baines / Demon Commander (voice)
Anders (voice) / Anders / Guard (voice)
Plasma / Griff (voice) / Additional Voices (voice)
Cavaliere (voice) / Captain / Fury 1 / Call Operator (voice)
Chi / Secretary 1 (voice) / Chi (voice)
Tom / Demon 2 (voice) / Tom / Chained Demon 1 (voice)
Argosax (voice) / Argosax / Demon Audience (voice)
Young Vergil (voice) / Young Vergil / Boy (voice)
Mattie (voice) / Additional Voices (voice)
Mother / Baby / Demon Kid (voice) / Mother / News Anchor / Waitress (voice)
Young Dante (voice)
News Anchor / Senator / Priest (voice) / Large Soldier (voice)
Hopper / Demon 1 (voice) / Pres. Hopper / Late Night Host (voice)
Predator Demon (voice) / Fallen / Fanged Demon (voice)
King (voice)
