John H. Watson (voice) / Unknown actor / Prostitute / Old man (voice)
William James Moriarty (voice)
Albert James Moriarty (voice)
Louis James Moriarty (voice)
Sherlock Holmes (voice)
Sebastian Moran (voice)
Fred Porlock (voice)
Reporter (voice) / Yard (voice)
Old Woman (voice) / Maggie (voice)
Nobleman (voice) / President (voice)
Robinson (voice) / Lawyer (voice)
George Lestrade (voice)
James Bonde (voice) / Irene Adler (voice)
Miss Hudson (voice)
Reporter (voice) / Barber (voice)
Mycroft Holmes (voice)
Boy (voice) / Young lady A (voice)
Charles Augustus Milverton (voice)
Jack Renfield (voice)
William James Moriarty (young) (voice)
Simon (voice) / Gregson (voice)
Yard (voice) / Railway staff C (voice)
Harry (voice) / Worker A (voice)
Wiggins (voice) / Boy (voice)
