Captain Underpants / Mr. Krupp (voice)
Harold (voice)
George (voice)
Narrator (voice)
Comic Narrator (voice)
Melvin (voice) / Melvin / Melvinborg (voice)
Jessica / Dressy (voice)
Steve 'Gooch' Yamaguchi (voice)
Erica (voice) / Grace Wain (voice)
Ms. Ribble (voice) / Ms. Ribble / Malison Saurus (voice)
Mr. Meaner (voice) / Mr. Meaner / Flabby Flabulous (voice)
Miss Anthrope (voice) / Miss Anthrope / Chalice Aristocrab (voice)
Mr. Ree (voice) / Mr. Ree / Splotch (voice)
Rap Talkwell (voice) / Robius (voice)
Diddlysaurus / The Schmoozer (voice) / Diddlysaurus / Fingers (voice)
Melvin's Mom (voice) / Harold's Mom / Melvin's Mom (voice)
Nanozero / Flash Flood (voice) / Cash Networth / Salamangler (voice)
Ms. Hurd / DJ Drowsy Drawers (voice) / Ms. Hurd (voice)
Ms. Yewh / TP Mummy (voice) / Lunch Lady (voice)
Smartsy Fartsy (voice)
Furculees / Chief Hairococha (voice) / Keithicus / Rippedicus / Guardicus (voice)
Hank (voice) / Laserlightmare (voice)
Lane Junkston (voice)
Tubbadump (voice)
